Frequently Asked Questions
PharmaNAC is N-acetylcysteine or “NAC”, which is a derivative of the amino acid L-cysteine, an essential precursor used by the body to produce glutathione. Glutathione is the most important and powerful antioxidant used by the body to help protect against free radical damage, and is a critical factor in supporting a healthy immune and respiratory system.*
Once ingested PharmaNAC is quickly de-acetylated and metabolized in the intestines and liver, where it is then ready to combine with glycine and glutamate to form glutathione.*
There is no known side effect to taking NAC, as it is derived from an amino acid your body currently utilizes. It is generally recognized as safe. Abdominal discomfort or nausea may occur when taking large quantities of over 7 tablets or 6.9 grams per day.
The recommended serving is two tablets per day. Avoid taking with any dairy products as the acidity of PharmaNAC is close to that of orange juice. PharmaNAC may be taken with or without food. It is recommended to be taken at morning and night, for a total of two to four tablets per day, or as recommended by your health care practitioner.*
Glutathione is an extremely important and powerful antioxidant produced by the body to help protect against free radical damage. and support good functioning in practically every cell. The free radicals that damage to our cells are neutralized by antioxidants such as glutathione. Glutathione exists in two forms in the human body; the first form is the reduced form which is the useful antioxidant that we want to have. Glutathione in its reduced form is able to donate an electron to an electron deficient free radical to reduce the free radical and eliminate it. When glutathione donates that electron, it becomes oxidized and unstable. With one electron missing glutathione binds to another oxidized glutathione molecule that has also given up one its electrons to from glutathione disulfide (GSSH). GSSH is a stable form of glutathione and can be reduced back to a single molecule through redox reactions (reactions involving electron transfers from one molecule to another) in the body.*
Glutathione levels in the body are reduced by several factors such as overall health, lifestyle, physical activity and environment. Considering these factors, it is important to ensure the body is able to obtain adequate amounts of cysteine to produce enough glutathione to protect the body from other damaging factors.*
NAC is a natural product derived from cysteine. Inactivations of some antibiotics have been observed in vitro when mixed with N-acetylcysteine such as semi-synthetic penicillins, tetracyclines, cephalosporins and aminoglycosides. When on these medications we recommend taking 2 hours apart from PharmaNAC so they do not mix together in your stomach. For antibiotics such as amoxicillin, doxycycline, erythromycin, thiamphenicole and cefuroxime no incompatibilities were found. We do however recommend consulting your health care practitioner when taking NAC with medications.
NAC has been around for a long time and is one of the most researched amino acid derivatives, so it’s no surprise you’ll find it in your local health store. NAC however is easily oxidized when exposed to air and an open bottle of capsules is very vulnerable to oxidation and degradation. We and other labs have found that inexpensive NAC available in capsules often contains significant impurities, and less NAC than is stated on the label.
BioAdvantex individually wraps each PharmaNAC tablet in 4-layer seal to protect each tablet from degradation and oxidation. PharmaNAC also delivers 900mg per tablet and is available in an effervescent form providing an alternative for those who have difficulty swallowing capsules, especially young children. Solid capsules or tablets are dissolved gradually in the stomach and depending on the individual physiological factors capsules may not fully dissolve and cause irritation on the mucous membrane of the stomach. Effervescent tablets allow for an even distribution of NAC concentration and create a balanced buffered solution for easy absorption. PharmaNAC flavors NAC with a great Wildberry taste, providing you with an enjoyable fizzy drink.
1. Sjodin K, Nilsson E, Hallberg A, Tunek A. Metabolism of N-acetyl-l-cysteine. Biochem Pharm 1989;38:3981-3985.
*THESE STATEMENTS HAS NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.